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Year : 2023  |  Volume : 3  |  Issue : 1  |  Page : 12-16

A perspective on gut health: The redox potential and pH

1 MYAS-NIN Department of Sports Science, Extension and Training Division, ICMR National Institute of Nutrition, Hyderabad, Telangana, India
2 Center of Excellence for Clinical Microbiome Research; Department of Biochemistry, All India Institute of Medical Sciences, Bhubaneswar, Odisha, India

Correspondence Address:
Balamurugan Ramadass
Department of Biochemistry, Head, Center of Excellence for Clinical Microbiome Research, All India Institute of Medical Sciences, Bhubaneswar - 751 019, Odisha
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ghep.ghep_38_22

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The diet, microbiota, and gut epithelium primarily determine gut health. Two fundamental physiochemical factors that regulate and coordinate the interaction between these three determinants of gut health are the redox potential (Eh) and pH. The Eh-pH coordinates determine the solubility, bioavailability, and toxicity of macronutrients and micronutrients. There is spatial heterogeneity in the redox potential, pH, and microbial composition/density both along and across the lumen of the Gastrointestinal (GI) tract. The optimal functioning of any compartment within the GI tract depends on its Eh-pH coordinates. Any abnormal deviation will likely result in pathophysiology and a shift in its resident flora to suit the altered Eh-pH state. Diet and digested products have a significant influence in regulating the local Eh-pH coordinates along with the microbiome and the mucosal secretions. This review emphasizes the importance and the need for simultaneous Eh-pH assessment of the lumen and mucosa of various compartments of GI tract in diagnosis and treatment. Since pH is a well-studied variable in the context of the gut, this minireview will focus on the relation between redox potential and gut health/disease.

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