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Year : 2022  |  Volume : 2  |  Issue : 3  |  Page : 103-105

Hepatitis with Syncytial Giant Cells in an Elderly Man: A Rare Histopathological Entity

1 Department of Pathology, The Rotherham NHS Foundation Trust, Rotherham, United Kingdom
2 Department of Pathology, Jawaharlal Nehru Medical College, Faculty of Medicine, A.M.U., Aligarh, Uttar Pradesh, India

Correspondence Address:
Kafil Akhtar
Department of Pathology, Jawaharlal Nehru Medical College, Aligarh Muslim University, Aligarh, Uttar Pradesh
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Source of Support: None, Conflict of Interest: None

DOI: 10.4103/ghep.ghep_15_22

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Giant cell transformation of hepatocytes is a nonspecific tissue reaction in neonates that is rarely seen outside of infancy. In children, it is particularly striking in cholestatic disorders and is prominent in neonatal hepatitis. In older patients, the presence of numerous hepatocyte giant cells is termed adult or postinfantile giant cell hepatitis (PIGCH) or syncytial giant cell hepatitis. About 25.0% of reported patients with PIGCH remain stable or have a gradual resolution of the disease. Corticosteroid treatment results in improvement in some but not all patients, and in the setting of autoimmune hepatitis, the clinical course may be progressive. We present a rare case of adult giant cell syncytial hepatitis with associated steatosis in a 79-year-old male, who presented with complaints of abdominal fullness, nausea, loss of appetite, and jaundice for the past 1 month.

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